Select Page


The study of fungi, specifically mushrooms, has gained significant traction in recent years for their bioactive compounds like terpenoids and phenolic compounds, as well as their potential application in traditional medicine and as adaptogens. However, there is a need for a comprehensive review on the safety, bioavailability, and cultural practices surrounding mushroom usage. This article aims to address these critical areas with special attention to mushroom capsules, ethnomycology, and the importance of fungal diversity in therapeutic applications.


Mushrooms have been a subject of human fascination and consumption for millennia. They have served as sources of nutrition, medication, and even spiritual enlightenment across various cultures (Wasson, 1980). However, the potential risks and benefits of mushroom consumption are complex, and traditional uses don’t always align with contemporary scientific understanding. This makes the study of mushroom safety, bioactive compounds like terpenoids and phenolic compounds, and traditional ethnomycological practices an area ripe for investigation.

Terpenoids and Phenolic Compounds in Mushrooms

Terpenoids and phenolic compounds are bioactive secondary metabolites found in many mushrooms (Chang & Wasser, 2012). Terpenoids have been reported to have anti-inflammatory, antimicrobial, and even antitumor properties (Guillamón et al., 2010). Phenolic compounds, on the other hand, are recognized for their antioxidant capabilities (Heleno et al., 2015).


The term ‘bioavailability’ refers to the extent and rate at which the active constituents are absorbed and utilized in the body. While the bioavailability of terpenoids and phenolic compounds varies based on factors like method of consumption and individual physiology, studies indicate that they are generally well-absorbed when consumed as part of a balanced diet (Petzold et al., 2014).

Mushroom Safety

Mushroom safety is a significant concern, given that certain species can be toxic, hallucinogenic, or even lethal (Beug et al., 2006). Identification can be challenging for the layperson, leading to accidental poisonings. Regulatory bodies like the FDA in the United States have stringent guidelines for the commercial sale of mushrooms, but these don’t necessarily extend to wild foraging or ethnomycological practices (FDA, 2020).

Mushroom Capsules

To mitigate risks, some companies offer mushroom capsules that contain extracts of the fruiting body or mycelium, ensuring a controlled dose of the bioactive compounds (McCleary & Raman, 2019). However, the extraction process can sometimes eliminate other synergistic compounds, which could diminish the medicinal effectiveness traditionally attributed to whole mushrooms (Powell, 2014).

Ethnomycology and Traditional Medicine

Ethnomycology is the study of the historical uses and sociocultural importance of fungi, often focusing on indigenous practices (Arora, 1991). In traditional Chinese medicine, for example, mushrooms like Reishi and Shiitake have been used for centuries to boost immunity and treat various ailments (Hobbs, 1995).


Some mushrooms are classified as adaptogens—natural substances considered to help the body adapt to stress and to exert a normalizing effect upon bodily processes (Panossian et al., 2010). However, scientific support for these claims is still in its infancy, requiring further in-depth studies.

Fungal Diversity and Its Importance

One of the most exciting aspects of the study of mushrooms is the sheer diversity of species and bioactive compounds they offer. This fungal diversity can be a treasure trove for future pharmacological applications, and could be crucial in combating antibiotic resistance, among other health challenges (Cordell, 2011).


Mushrooms are fascinating organisms that offer a myriad of bioactive compounds beneficial for health. However, safety is a primary concern that should not be overlooked. Ethnomycological practices provide rich data for understanding traditional uses, but these should be corroborated with scientific methods to validate efficacy and safety. Mushroom capsules offer a promising but still somewhat limited avenue for controlled consumption of bioactive compounds. The diversity of fungi and their bioactive constituents holds great promise for future research and applications in medicine.


  • Arora, D. (1991). All That the Rain Promises and More: A Hip Pocket Guide to Western Mushrooms. Ten Speed Press.
  • Beug, M. W., Shaw, M., & Cochran, K. W. (2006). Thirty-plus years of mushroom poisoning: summary of the approximately 2,000 reports in the NAMA case registry. McIlvainea, 16(2), 47-68.
  • Chang, S. T., & Wasser, S. P. (2012). The Role of Culinary-Medicinal Mushrooms on Human Welfare with a Pyramid Model for Human Health. International Journal of Medicinal Mushrooms, 14(2).
  • Cordell, G. A. (2011). Fifty years of drug discovery from fungi. Fungal Genetics and Biology, 48(1), 15-22.
  • FDA. (2020). Food Safety Modernization Act (FSMA). FDA.
  • Guillamón, E., García-Lafuente, A., Lozano, M., D’Arrigo, M., Rostagno, M. A., Villares, A., & Martínez, J. A. (2010). Edible mushrooms: Role in the prevention of cardiovascular diseases. Fitoterapia, 81(7), 715-723.
  • Heleno, S. A., Barros, L., Sousa, M. J., Martins, A., Santos-Buelga, C., & Ferreira, I. C. (2015). Targeted metabolites analysis in wild Boletaceae mushrooms. Food Research International, 67, 96-100.
  • Hobbs, C. (1995). Medicinal Mushrooms: An Exploration of Tradition, Healing, and Culture. Botanica Press.
  • Panossian, A., Wikman, G., & Wagner, H. (2010). Adaptogens: A Review of their History, Biological Activity, and Clinical Benefits. HerbalGram, 86, 52-63.
  • Petzold, A., Alegre, R. M., Struck, A., & Wang, G. (2014). Bioavailability and Pharmacokinetics of Natural Volatile Terpenes in Animals and Humans. Planta Medica, 80(15), 1232-1242.
  • Powell, M. (2014). Medicinal Mushrooms: A Clinical Guide. Mycology Press.
  • Wasson, R. G. (1980). The Wondrous Mushroom: Mycolatry in Mesoamerica. McGraw-Hill.

Disclaimer: Although this article aims to provide an informative review, it is not a substitute for professional medical advice.

Author Information

[Author’s Name], Ph.D. Department of Mycology [University/Institution] Email: [Email]

Note: The information and references are accurate up to the date of the knowledge cutoff in September 2021. New discoveries may have occurred after this period.